Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation. We report that lactate accumulation in the inflamed tissue contributes to the upregulation of t...

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Detalles Bibliográficos
Autores principales: Pucino, Valentina, Certo, Michelangelo, Bulusu, Vinay, Cucchi, Danilo, Goldmann, Katriona, Pontarini, Elena, Haas, Robert, Smith, Joanne, Headland, Sarah E., Blighe, Kevin, Ruscica, Massimiliano, Humby, Frances, Lewis, Myles J., Kamphorst, Jurre J., Bombardieri, Michele, Pitzalis, Costantino, Mauro, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899510/
https://www.ncbi.nlm.nih.gov/pubmed/31708446
http://dx.doi.org/10.1016/j.cmet.2019.10.004

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