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In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Disassembly of the replisome is the final step of chromosome duplication in eukaryotes. In budding yeast and metazoa, cullin ubiquitin ligases are required to ubiquitylate the Cdc45-MCM-GINS (CMG) helicase that lies at the heart of the replisome, leading to a disassembly reaction that is dependent u...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Progya P., Labib, Karim P.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899518/ https://www.ncbi.nlm.nih.gov/pubmed/31509741 http://dx.doi.org/10.1016/j.celrep.2019.08.026

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