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The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials

AIM: To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF(2)) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months. MATERIALS AND METHODS: A meta‐analysis evaluated bioavailable glucona...

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Autores principales: Biesbrock, Aaron, He, Tao, DiGennaro, Joe, Zou, Yuanshu, Ramsey, Dave, Garcia‐Godoy, Franklin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899529/
https://www.ncbi.nlm.nih.gov/pubmed/31562774
http://dx.doi.org/10.1111/jcpe.13203
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author Biesbrock, Aaron
He, Tao
DiGennaro, Joe
Zou, Yuanshu
Ramsey, Dave
Garcia‐Godoy, Franklin
author_facet Biesbrock, Aaron
He, Tao
DiGennaro, Joe
Zou, Yuanshu
Ramsey, Dave
Garcia‐Godoy, Franklin
author_sort Biesbrock, Aaron
collection PubMed
description AIM: To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF(2)) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months. MATERIALS AND METHODS: A meta‐analysis evaluated bioavailable gluconate chelated SnF(2) dentifrices versus a negative or positive control for gingival bleeding. RESULTS: In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF(2) paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was −16.3 (−27.8, −4.9) versus the negative control and −3.6 (−5.4, −1.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF(2) versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF(2) versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias. CONCLUSION: This meta‐analysis demonstrates significant gingivitis benefits of bioavailable SnF(2) dentifrices when used ≤3 months versus positive (triclosan) and negative (NaF or MFP) controls.
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spelling pubmed-68995292019-12-19 The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials Biesbrock, Aaron He, Tao DiGennaro, Joe Zou, Yuanshu Ramsey, Dave Garcia‐Godoy, Franklin J Clin Periodontol Periodontal Therapy AIM: To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF(2)) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months. MATERIALS AND METHODS: A meta‐analysis evaluated bioavailable gluconate chelated SnF(2) dentifrices versus a negative or positive control for gingival bleeding. RESULTS: In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF(2) paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was −16.3 (−27.8, −4.9) versus the negative control and −3.6 (−5.4, −1.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF(2) versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF(2) versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias. CONCLUSION: This meta‐analysis demonstrates significant gingivitis benefits of bioavailable SnF(2) dentifrices when used ≤3 months versus positive (triclosan) and negative (NaF or MFP) controls. John Wiley and Sons Inc. 2019-11-14 2019-12 /pmc/articles/PMC6899529/ /pubmed/31562774 http://dx.doi.org/10.1111/jcpe.13203 Text en © 2019 John Wiley & Sons A/S. published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Periodontal Therapy
Biesbrock, Aaron
He, Tao
DiGennaro, Joe
Zou, Yuanshu
Ramsey, Dave
Garcia‐Godoy, Franklin
The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title_full The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title_fullStr The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title_full_unstemmed The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title_short The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
title_sort effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: meta‐analysis of eighteen randomized controlled trials
topic Periodontal Therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899529/
https://www.ncbi.nlm.nih.gov/pubmed/31562774
http://dx.doi.org/10.1111/jcpe.13203
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