Concerted Nucleophilic Aromatic Substitution Reactions

Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two‐step, S(N)Ar mechanisms. Whereas traditional S(N)Ar reactions require substantial activation o...

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Detalles Bibliográficos
Autores principales: Rohrbach, Simon, Smith, Andrew J., Pang, Jia Hao, Poole, Darren L., Tuttle, Tell, Chiba, Shunsuke, Murphy, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899550/
https://www.ncbi.nlm.nih.gov/pubmed/30990931
http://dx.doi.org/10.1002/anie.201902216
Descripción
Sumario:Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two‐step, S(N)Ar mechanisms. Whereas traditional S(N)Ar reactions require substantial activation of the aromatic ring by electron‐withdrawing substituents, such activating groups are not mandatory in the concerted pathways.

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