Concerted Nucleophilic Aromatic Substitution Reactions

Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two‐step, S(N)Ar mechanisms. Whereas traditional S(N)Ar reactions require substantial activation o...

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Detalles Bibliográficos
Autores principales: Rohrbach, Simon, Smith, Andrew J., Pang, Jia Hao, Poole, Darren L., Tuttle, Tell, Chiba, Shunsuke, Murphy, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899550/
https://www.ncbi.nlm.nih.gov/pubmed/30990931
http://dx.doi.org/10.1002/anie.201902216
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author Rohrbach, Simon
Smith, Andrew J.
Pang, Jia Hao
Poole, Darren L.
Tuttle, Tell
Chiba, Shunsuke
Murphy, John A.
author_facet Rohrbach, Simon
Smith, Andrew J.
Pang, Jia Hao
Poole, Darren L.
Tuttle, Tell
Chiba, Shunsuke
Murphy, John A.
author_sort Rohrbach, Simon
collection PubMed
description Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two‐step, S(N)Ar mechanisms. Whereas traditional S(N)Ar reactions require substantial activation of the aromatic ring by electron‐withdrawing substituents, such activating groups are not mandatory in the concerted pathways.
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spelling pubmed-68995502019-12-19 Concerted Nucleophilic Aromatic Substitution Reactions Rohrbach, Simon Smith, Andrew J. Pang, Jia Hao Poole, Darren L. Tuttle, Tell Chiba, Shunsuke Murphy, John A. Angew Chem Int Ed Engl Reviews Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS(N)Ar) rather than classical, two‐step, S(N)Ar mechanisms. Whereas traditional S(N)Ar reactions require substantial activation of the aromatic ring by electron‐withdrawing substituents, such activating groups are not mandatory in the concerted pathways. John Wiley and Sons Inc. 2019-09-13 2019-11-11 /pmc/articles/PMC6899550/ /pubmed/30990931 http://dx.doi.org/10.1002/anie.201902216 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Rohrbach, Simon
Smith, Andrew J.
Pang, Jia Hao
Poole, Darren L.
Tuttle, Tell
Chiba, Shunsuke
Murphy, John A.
Concerted Nucleophilic Aromatic Substitution Reactions
title Concerted Nucleophilic Aromatic Substitution Reactions
title_full Concerted Nucleophilic Aromatic Substitution Reactions
title_fullStr Concerted Nucleophilic Aromatic Substitution Reactions
title_full_unstemmed Concerted Nucleophilic Aromatic Substitution Reactions
title_short Concerted Nucleophilic Aromatic Substitution Reactions
title_sort concerted nucleophilic aromatic substitution reactions
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899550/
https://www.ncbi.nlm.nih.gov/pubmed/30990931
http://dx.doi.org/10.1002/anie.201902216
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AT tuttletell concertednucleophilicaromaticsubstitutionreactions
AT chibashunsuke concertednucleophilicaromaticsubstitutionreactions
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