Infection with genotoxin‐producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells

Several commensal and pathogenic Gram‐negative bacteria produce DNA‐damaging toxins that are considered bona fide carcinogenic agents. The microbiota of colorectal cancer (CRC) patients is enriched in genotoxin‐producing bacteria, but their role in the pathogenesis of CRC is poorly understood. The a...

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Detalles Bibliográficos
Autores principales: Martin, Océane C.B., Bergonzini, Anna, D'Amico, Federica, Chen, Puran, Shay, Jerry W., Dupuy, Jacques, Svensson, Mattias, Masucci, Maria G., Frisan, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899655/
https://www.ncbi.nlm.nih.gov/pubmed/31414579
http://dx.doi.org/10.1111/cmi.13099

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