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Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI

ESSENTIALS: Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the N‐terminal apple domains to recruit substrates. A high‐resolution 1.3 Å structure of full‐length PKa reveals an active confo...

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Detalles Bibliográficos
Autores principales:	Li, Chan, Voos, Kayleigh M., Pathak, Monika, Hall, Gareth, McCrae, Keith R., Dreveny, Ingrid, Li, Renhao, Emsley, Jonas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	THROMBOSIS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899681/ https://www.ncbi.nlm.nih.gov/pubmed/30801944 http://dx.doi.org/10.1111/jth.14418

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