Bioactivation mechanisms of N‐hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids

Aristolochic acids (AAs) are human nephrotoxins and carcinogens found in concoctions of Aristolochia plants used in traditional medicinal practices worldwide. Genotoxicity of AAs is associated with the formation of active species catalyzed by metabolic enzymes, the full repertoire of which is unknow...

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Detalles Bibliográficos
Autores principales: Okuno, Yoshiharu, Bonala, Radha, Attaluri, Sivaprasad, Johnson, Francis, Grollman, Arthur P., Sidorenko, Viktoriya S., Oda, Yoshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899766/
https://www.ncbi.nlm.nih.gov/pubmed/31374128
http://dx.doi.org/10.1002/em.22321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899766/
https://www.ncbi.nlm.nih.gov/pubmed/31374128
http://dx.doi.org/10.1002/em.22321

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