Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

In bone, sclerostin is mainly osteocyte‐derived and plays an important local role in adaptive responses to mechanical loading. Whether circulating levels of sclerostin also play a functional role is currently unclear, which we aimed to examine by two‐sample Mendelian randomization (MR). A genetic in...

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Detalles Bibliográficos
Autores principales: Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus, Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M, Medina‐Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young‐Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H, Nilsson, Karin H, Movérare‐Skrtic, Sofia, Baird, Denis, Elsworth, Benjamin, Falk, Louise, Groom, Alix, Capellini, Terence D, Grundberg, Elin, Nethander, Maria, Ohlsson, Claes, Davey Smith, George, Tobias, Jonathan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899787/
https://www.ncbi.nlm.nih.gov/pubmed/31170332
http://dx.doi.org/10.1002/jbmr.3803

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