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Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti

Pyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. Because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure...

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Autores principales: Norris, E. J., Gross, A. D., Bartholomay, L. C., Coats, J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899815/
https://www.ncbi.nlm.nih.gov/pubmed/31102301
http://dx.doi.org/10.1111/mve.12380
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author Norris, E. J.
Gross, A. D.
Bartholomay, L. C.
Coats, J. R.
author_facet Norris, E. J.
Gross, A. D.
Bartholomay, L. C.
Coats, J. R.
author_sort Norris, E. J.
collection PubMed
description Pyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. Because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure of pyrethroid‐based insecticides brought about by increasing pyrethroid resistance. As a result, innovative approaches are desperately needed to overcome insecticide resistance, particularly in mosquitoes that transmit deadly and debilitating pathogens. Numerous studies have demonstrated the potential of plant essential oils to enhance the efficacy of pyrethroids. The toxicity of pyrethroids combined with plant oils is significantly greater than the baseline toxicity of either oils or pyrethroids applied alone, which suggests there are synergistic interactions between components of these mixtures. The present study examined the potential of eight plant essential oils applied in one of two concentrations (1% and 5%) to enhance the toxicity of various pyrethroids (permethrin, natural pyrethrins, deltamethrin and β‐cyfluthrin). The various plant essential oils enhanced the pyrethroids to differing degrees. The levels of enhancement provided by combinations of plant essential oils and pyrethroids in comparison with pyrethroids alone were calculated and synergistic outcomes characterized. Numerous plant essential oils significantly synergized a variety of pyrethroids; type I pyrethroids were synergized to a greater degree than type II pyrethroids. Eight plant essential oils significantly enhanced 24‐h mortality rates provided by permethrin and six plant essential oils enhanced 24‐h mortality rates obtained with natural pyrethrins. By contrast, only three plant essential plants significantly enhanced the toxicity of deltamethrin and β‐cyfluthrin. Of the plant essential oils that enhanced the toxicity of these pyrethroids, some produced varying levels of synergism and antagonism. Geranium, patchouli and Texas cedarwood oils produced the highest levels of synergism, displaying co‐toxicity factors of > 100 in some combinations. To assess the levels of enhancement and synergism of other classes of insecticide, malathion was also applied in combination with the plant oils. Significant antagonism was provided by a majority of the plant essential oils applied in combination with this insecticide, which suggests that plant essential oils may act to inhibit the oxidative activation processes within exposed adult mosquitoes.
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spelling pubmed-68998152019-12-19 Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti Norris, E. J. Gross, A. D. Bartholomay, L. C. Coats, J. R. Med Vet Entomol Original Articles Pyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. Because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure of pyrethroid‐based insecticides brought about by increasing pyrethroid resistance. As a result, innovative approaches are desperately needed to overcome insecticide resistance, particularly in mosquitoes that transmit deadly and debilitating pathogens. Numerous studies have demonstrated the potential of plant essential oils to enhance the efficacy of pyrethroids. The toxicity of pyrethroids combined with plant oils is significantly greater than the baseline toxicity of either oils or pyrethroids applied alone, which suggests there are synergistic interactions between components of these mixtures. The present study examined the potential of eight plant essential oils applied in one of two concentrations (1% and 5%) to enhance the toxicity of various pyrethroids (permethrin, natural pyrethrins, deltamethrin and β‐cyfluthrin). The various plant essential oils enhanced the pyrethroids to differing degrees. The levels of enhancement provided by combinations of plant essential oils and pyrethroids in comparison with pyrethroids alone were calculated and synergistic outcomes characterized. Numerous plant essential oils significantly synergized a variety of pyrethroids; type I pyrethroids were synergized to a greater degree than type II pyrethroids. Eight plant essential oils significantly enhanced 24‐h mortality rates provided by permethrin and six plant essential oils enhanced 24‐h mortality rates obtained with natural pyrethrins. By contrast, only three plant essential plants significantly enhanced the toxicity of deltamethrin and β‐cyfluthrin. Of the plant essential oils that enhanced the toxicity of these pyrethroids, some produced varying levels of synergism and antagonism. Geranium, patchouli and Texas cedarwood oils produced the highest levels of synergism, displaying co‐toxicity factors of > 100 in some combinations. To assess the levels of enhancement and synergism of other classes of insecticide, malathion was also applied in combination with the plant oils. Significant antagonism was provided by a majority of the plant essential oils applied in combination with this insecticide, which suggests that plant essential oils may act to inhibit the oxidative activation processes within exposed adult mosquitoes. Blackwell Publishing Ltd 2019-05-17 2019-12 /pmc/articles/PMC6899815/ /pubmed/31102301 http://dx.doi.org/10.1111/mve.12380 Text en © 2019 The Authors. Medical and Veterinary Entomology published by John Wiley & Sons Ltd on behalf of Royal Entomological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Norris, E. J.
Gross, A. D.
Bartholomay, L. C.
Coats, J. R.
Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title_full Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title_fullStr Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title_full_unstemmed Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title_short Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti
title_sort plant essential oils synergize various pyrethroid insecticides and antagonize malathion in aedes aegypti
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899815/
https://www.ncbi.nlm.nih.gov/pubmed/31102301
http://dx.doi.org/10.1111/mve.12380
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