Cargando…

A Phase 1, Open‐Label, Pharmacokinetic Trial to Investigate Possible Drug‐Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects

GW Pharmaceuticals’ formulation of highly purified cannabidiol oral solution is approved in the United States for seizures associated with Lennox‐Gastaut and Dravet syndromes in patients aged ≥2 years, for which clobazam, stiripentol, and valproate are commonly used antiepileptic drugs. This open‐la...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morrison, Gilmour, Crockett, Julie, Blakey, Graham, Sommerville, Kenneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899822/ https://www.ncbi.nlm.nih.gov/pubmed/30791225 http://dx.doi.org/10.1002/cpdd.665

Ejemplares similares

A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug–Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy
por: Ben-Menachem, Elinor, et al.
Publicado: (2020)

A Phase 2, Double‐Blind, Placebo‐Controlled Trial to Investigate Potential Drug‐Drug Interactions Between Cannabidiol and Clobazam
por: VanLandingham, Kevan E., et al.
Publicado: (2020)

A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects
por: Boyd, Brooks, et al.
Publicado: (2019)

A Phase 1, Open‐Label, Parallel‐Group, Single‐Dose Trial of the Pharmacokinetics and Safety of Cannabidiol (CBD) in Subjects With Mild to Severe Hepatic Impairment
por: Taylor, Lesley, et al.
Publicado: (2019)

Cannabidiol efficacy independent of clobazam: Meta‐analysis of four randomized controlled trials
por: Devinsky, Orrin, et al.
Publicado: (2020)

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
por: Anderson, Lyndsey L., et al.
Publicado: (2019)

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
por: Taylor, Lesley, et al.
Publicado: (2018)

A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects
por: Crockett, Julie, et al.
Publicado: (2020)

Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials
por: Gunning, Boudewijn, et al.
Publicado: (2020)

A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment
por: Tayo, Bola, et al.
Publicado: (2019)

A Comprehensive Overview of the Clinical Pharmacokinetics of Clobazam
por: Tolbert, Dwain, et al.
Publicado: (2018)

Stiripentol for Dravet syndrome
Publicado: (2020)

Effect of clobazam as add-on antiepileptic drug in patients with epilepsy
por: Joshi, Rupa, et al.
Publicado: (2014)

Clobazam: The phoenix drug (from the very old to the brand new)
por: Guerreiro, Carlos A. M.
Publicado: (2014)

Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
por: Afifi, Samar
Publicado: (2015)

Antiepileptic Stiripentol May Influence Bones
por: Matuszewska, Agnieszka, et al.
Publicado: (2021)

Deconstructing tolerance with clobazam: Post hoc analyses from an open-label extension study
por: Gidal, Barry E., et al.
Publicado: (2016)

Clinical implications of trials investigating drug‐drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs
por: Patsalos, Philip N., et al.
Publicado: (2020)

Audit of use of stiripentol in adults with Dravet syndrome
por: Balestrini, S., et al.
Publicado: (2016)

Is stiripentol truly effective for treating primary hyperoxaluria?
por: Martin-Higueras, Cristina, et al.
Publicado: (2020)

The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects
por: Markowitz, John S., et al.
Publicado: (2022)

Clobazam and Its Use in Epilepsy
por: Pernea, Marius, et al.
Publicado: (2016)

Use and cost comparison of clobazam to other antiepileptic drugs for treatment of Lennox-Gastaut syndrome
por: François, Clément, et al.
Publicado: (2017)

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome
por: Devinsky, Orrin, et al.
Publicado: (2018)

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia
por: Ralvenius, William T., et al.
Publicado: (2016)

A Phase 1 Open‐Label, Fixed‐Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects
por: Thai, Ching, et al.
Publicado: (2021)

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
por: Meirinho, Sara, et al.
Publicado: (2021)

Formulation and optimization of fast dissolving intraoral drug delivery system for clobazam using response surface methodology
por: Bala, Rajni, et al.
Publicado: (2013)

Hypothermia associated with clobazam use in adult epilepsy
por: Gauthier, Angela C., et al.
Publicado: (2016)

Effects of clobazam for treatment of refractory status epilepticus
por: Madžar, Dominik, et al.
Publicado: (2016)

Commentary: Targeting LDH enzymes with a stiripentol analog to treat epilepsy
por: Cho, Chang-Hoon
Publicado: (2015)

Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
por: Cho, Min Jung, et al.
Publicado: (2018)

Efficacy and Safety of Long-Term Treatment with Stiripentol in Children and Adults with Drug-Resistant Epilepsies: A Retrospective Cohort Study of 196 Patients
por: Balestrini, Simona, et al.
Publicado: (2022)

Systematic review of clobazam use in patients with status epilepticus
por: Mahmoud, Sherif Hanafy, et al.
Publicado: (2018)

Effect of plasmapheresis on serum levels of clobazam, levetiracetam and topiramate
por: Hau Man, To Harmony, et al.
Publicado: (2017)

Drug-Drug Interactions Between Cannabidiol and Lithium
por: Singh, Rani K., et al.
Publicado: (2020)

Psoriasiform Drug Eruption Associated with Sodium Valproate
por: Gul Mert, Gulen, et al.
Publicado: (2013)

Nanoemulsions as novel oral carriers of stiripentol: insights into the protective effect and absorption enhancement
por: Lu, Rong, et al.
Publicado: (2015)

Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model – Phenytoin and Valproate, Lamotrigine and Valproate
por: Taing, Kim Det, et al.
Publicado: (2017)

Evaluation of efficacy and safety of clobazam as an add-on drug in the treatment of generalized tonic-clonic seizure not controlled with valproic acid monotherapy
por: Das, Somenath, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_606sluuvvedg8nnq1g5jo8d228