Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy

BACKGROUND: Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin‐2 reduces plasma triglycerides and may therefore be beneficial to reduce...

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Detalles Bibliográficos
Autores principales: Saliba‐Gustafsson, P., Pedrelli, M., Gertow, K., Werngren, O., Janas, V., Pourteymour, S., Baldassarre, D., Tremoli, E., Veglia, F., Rauramaa, R., Smit, A.J., Giral, P., Kurl, S., Pirro, M., de Faire, U., Humphries, S.E., Hamsten, A., Gonçalves, I., Orho‐Melander, M., Franco‐Cereceda, A., Borén, J., Eriksson, P., Magné, J., Parini, P., Ehrenborg, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899829/
https://www.ncbi.nlm.nih.gov/pubmed/31251843
http://dx.doi.org/10.1111/joim.12951

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