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Early retinal microvascular abnormalities in patients with chronic kidney disease
OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects we...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899838/ https://www.ncbi.nlm.nih.gov/pubmed/31066106 http://dx.doi.org/10.1111/micc.12555 |
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author | Yeung, Ling Wu, I‐Wen Sun, Chi‐Chin Liu, Chun‐Fu Chen, Shin‐Yi Tseng, Chung‐Hsin Lee, Hsin‐Chin Lee, Chin‐Chan |
author_facet | Yeung, Ling Wu, I‐Wen Sun, Chi‐Chin Liu, Chun‐Fu Chen, Shin‐Yi Tseng, Chung‐Hsin Lee, Hsin‐Chin Lee, Chin‐Chan |
author_sort | Yeung, Ling |
collection | PubMed |
description | OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) between the CKD and control groups. RESULTS: The mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 (P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP, whereas age, diabetes, and smoking were factors associated with vessel density in DVP. CONCLUSION: Patients with CKD had reduced vessel densities in parafoveal SVP and DVP, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors. |
format | Online Article Text |
id | pubmed-6899838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68998382019-12-19 Early retinal microvascular abnormalities in patients with chronic kidney disease Yeung, Ling Wu, I‐Wen Sun, Chi‐Chin Liu, Chun‐Fu Chen, Shin‐Yi Tseng, Chung‐Hsin Lee, Hsin‐Chin Lee, Chin‐Chan Microcirculation Original Articles OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) between the CKD and control groups. RESULTS: The mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 (P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP, whereas age, diabetes, and smoking were factors associated with vessel density in DVP. CONCLUSION: Patients with CKD had reduced vessel densities in parafoveal SVP and DVP, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors. John Wiley and Sons Inc. 2019-05-27 2019-10 /pmc/articles/PMC6899838/ /pubmed/31066106 http://dx.doi.org/10.1111/micc.12555 Text en © 2019 The Authors. Microcirculation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yeung, Ling Wu, I‐Wen Sun, Chi‐Chin Liu, Chun‐Fu Chen, Shin‐Yi Tseng, Chung‐Hsin Lee, Hsin‐Chin Lee, Chin‐Chan Early retinal microvascular abnormalities in patients with chronic kidney disease |
title | Early retinal microvascular abnormalities in patients with chronic kidney disease |
title_full | Early retinal microvascular abnormalities in patients with chronic kidney disease |
title_fullStr | Early retinal microvascular abnormalities in patients with chronic kidney disease |
title_full_unstemmed | Early retinal microvascular abnormalities in patients with chronic kidney disease |
title_short | Early retinal microvascular abnormalities in patients with chronic kidney disease |
title_sort | early retinal microvascular abnormalities in patients with chronic kidney disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899838/ https://www.ncbi.nlm.nih.gov/pubmed/31066106 http://dx.doi.org/10.1111/micc.12555 |
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