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Early retinal microvascular abnormalities in patients with chronic kidney disease

OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects we...

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Autores principales: Yeung, Ling, Wu, I‐Wen, Sun, Chi‐Chin, Liu, Chun‐Fu, Chen, Shin‐Yi, Tseng, Chung‐Hsin, Lee, Hsin‐Chin, Lee, Chin‐Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899838/
https://www.ncbi.nlm.nih.gov/pubmed/31066106
http://dx.doi.org/10.1111/micc.12555
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author Yeung, Ling
Wu, I‐Wen
Sun, Chi‐Chin
Liu, Chun‐Fu
Chen, Shin‐Yi
Tseng, Chung‐Hsin
Lee, Hsin‐Chin
Lee, Chin‐Chan
author_facet Yeung, Ling
Wu, I‐Wen
Sun, Chi‐Chin
Liu, Chun‐Fu
Chen, Shin‐Yi
Tseng, Chung‐Hsin
Lee, Hsin‐Chin
Lee, Chin‐Chan
author_sort Yeung, Ling
collection PubMed
description OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) between the CKD and control groups. RESULTS: The mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 (P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP, whereas age, diabetes, and smoking were factors associated with vessel density in DVP. CONCLUSION: Patients with CKD had reduced vessel densities in parafoveal SVP and DVP, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors.
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spelling pubmed-68998382019-12-19 Early retinal microvascular abnormalities in patients with chronic kidney disease Yeung, Ling Wu, I‐Wen Sun, Chi‐Chin Liu, Chun‐Fu Chen, Shin‐Yi Tseng, Chung‐Hsin Lee, Hsin‐Chin Lee, Chin‐Chan Microcirculation Original Articles OBJECTIVE: To evaluate early retinal microvascular abnormalities in patients with chronic kidney disease (CKD) via optical coherence tomography angiography. METHODS: A cross‐sectional study. Two hundred patients with CKD stage ≧3 were enrolled in the CKD group, and 50 age‐matched healthy subjects were enrolled in the control group. Main outcome measures were the differences in parafoveal vessel densities in the superficial vascular plexus (SVP) and deep vascular plexus (DVP) between the CKD and control groups. RESULTS: The mean ages were 62.7 ± 10.1 in the CKD group and 61.9 ± 9.7 (P = 0.622) in the control group. The CKD group had reduced parafoveal vessel densities in SVP (46.7 ± 4.3 vs 49.7 ± 2.9, P < 0.001) and DVP (50.1 ± 4.1 vs 52. 6 ± 2.9, P < 0.001) when compared to those of the control group. In multiple linear regression models, age, diabetes, estimated glomerular filtration rate, and use of anti‐hypertensive drugs were factors associated with vessel density in SVP, whereas age, diabetes, and smoking were factors associated with vessel density in DVP. CONCLUSION: Patients with CKD had reduced vessel densities in parafoveal SVP and DVP, as compared to that of control subjects. Microvasculature in the different retinal layers may be affected by different systemic factors. John Wiley and Sons Inc. 2019-05-27 2019-10 /pmc/articles/PMC6899838/ /pubmed/31066106 http://dx.doi.org/10.1111/micc.12555 Text en © 2019 The Authors. Microcirculation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yeung, Ling
Wu, I‐Wen
Sun, Chi‐Chin
Liu, Chun‐Fu
Chen, Shin‐Yi
Tseng, Chung‐Hsin
Lee, Hsin‐Chin
Lee, Chin‐Chan
Early retinal microvascular abnormalities in patients with chronic kidney disease
title Early retinal microvascular abnormalities in patients with chronic kidney disease
title_full Early retinal microvascular abnormalities in patients with chronic kidney disease
title_fullStr Early retinal microvascular abnormalities in patients with chronic kidney disease
title_full_unstemmed Early retinal microvascular abnormalities in patients with chronic kidney disease
title_short Early retinal microvascular abnormalities in patients with chronic kidney disease
title_sort early retinal microvascular abnormalities in patients with chronic kidney disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899838/
https://www.ncbi.nlm.nih.gov/pubmed/31066106
http://dx.doi.org/10.1111/micc.12555
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