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The role of microbiota in the development of colorectal cancer

Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into...

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Detalles Bibliográficos
Autores principales: Dai, Zhujiang, Zhang, Jingqiu, Wu, Qi, Chen, Juan, Liu, Jun, Wang, Lu, Chen, Chaowu, Xu, Jiaming, Zhang, Hongpeng, Shi, Chunfeng, Li, Zhen, Fang, Huiwen, Lin, Chaobiao, Tang, Dong, Wang, Daorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899977/
https://www.ncbi.nlm.nih.gov/pubmed/30474116
http://dx.doi.org/10.1002/ijc.32017
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author Dai, Zhujiang
Zhang, Jingqiu
Wu, Qi
Chen, Juan
Liu, Jun
Wang, Lu
Chen, Chaowu
Xu, Jiaming
Zhang, Hongpeng
Shi, Chunfeng
Li, Zhen
Fang, Huiwen
Lin, Chaobiao
Tang, Dong
Wang, Daorong
author_facet Dai, Zhujiang
Zhang, Jingqiu
Wu, Qi
Chen, Juan
Liu, Jun
Wang, Lu
Chen, Chaowu
Xu, Jiaming
Zhang, Hongpeng
Shi, Chunfeng
Li, Zhen
Fang, Huiwen
Lin, Chaobiao
Tang, Dong
Wang, Daorong
author_sort Dai, Zhujiang
collection PubMed
description Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation.
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spelling pubmed-68999772019-12-20 The role of microbiota in the development of colorectal cancer Dai, Zhujiang Zhang, Jingqiu Wu, Qi Chen, Juan Liu, Jun Wang, Lu Chen, Chaowu Xu, Jiaming Zhang, Hongpeng Shi, Chunfeng Li, Zhen Fang, Huiwen Lin, Chaobiao Tang, Dong Wang, Daorong Int J Cancer Mini Reviews Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation. John Wiley and Sons Inc. 2019-01-15 2019-10-15 /pmc/articles/PMC6899977/ /pubmed/30474116 http://dx.doi.org/10.1002/ijc.32017 Text en © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Mini Reviews
Dai, Zhujiang
Zhang, Jingqiu
Wu, Qi
Chen, Juan
Liu, Jun
Wang, Lu
Chen, Chaowu
Xu, Jiaming
Zhang, Hongpeng
Shi, Chunfeng
Li, Zhen
Fang, Huiwen
Lin, Chaobiao
Tang, Dong
Wang, Daorong
The role of microbiota in the development of colorectal cancer
title The role of microbiota in the development of colorectal cancer
title_full The role of microbiota in the development of colorectal cancer
title_fullStr The role of microbiota in the development of colorectal cancer
title_full_unstemmed The role of microbiota in the development of colorectal cancer
title_short The role of microbiota in the development of colorectal cancer
title_sort role of microbiota in the development of colorectal cancer
topic Mini Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899977/
https://www.ncbi.nlm.nih.gov/pubmed/30474116
http://dx.doi.org/10.1002/ijc.32017
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