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The role of microbiota in the development of colorectal cancer
Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899977/ https://www.ncbi.nlm.nih.gov/pubmed/30474116 http://dx.doi.org/10.1002/ijc.32017 |
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author | Dai, Zhujiang Zhang, Jingqiu Wu, Qi Chen, Juan Liu, Jun Wang, Lu Chen, Chaowu Xu, Jiaming Zhang, Hongpeng Shi, Chunfeng Li, Zhen Fang, Huiwen Lin, Chaobiao Tang, Dong Wang, Daorong |
author_facet | Dai, Zhujiang Zhang, Jingqiu Wu, Qi Chen, Juan Liu, Jun Wang, Lu Chen, Chaowu Xu, Jiaming Zhang, Hongpeng Shi, Chunfeng Li, Zhen Fang, Huiwen Lin, Chaobiao Tang, Dong Wang, Daorong |
author_sort | Dai, Zhujiang |
collection | PubMed |
description | Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation. |
format | Online Article Text |
id | pubmed-6899977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68999772019-12-20 The role of microbiota in the development of colorectal cancer Dai, Zhujiang Zhang, Jingqiu Wu, Qi Chen, Juan Liu, Jun Wang, Lu Chen, Chaowu Xu, Jiaming Zhang, Hongpeng Shi, Chunfeng Li, Zhen Fang, Huiwen Lin, Chaobiao Tang, Dong Wang, Daorong Int J Cancer Mini Reviews Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation. John Wiley and Sons Inc. 2019-01-15 2019-10-15 /pmc/articles/PMC6899977/ /pubmed/30474116 http://dx.doi.org/10.1002/ijc.32017 Text en © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Mini Reviews Dai, Zhujiang Zhang, Jingqiu Wu, Qi Chen, Juan Liu, Jun Wang, Lu Chen, Chaowu Xu, Jiaming Zhang, Hongpeng Shi, Chunfeng Li, Zhen Fang, Huiwen Lin, Chaobiao Tang, Dong Wang, Daorong The role of microbiota in the development of colorectal cancer |
title | The role of microbiota in the development of colorectal cancer |
title_full | The role of microbiota in the development of colorectal cancer |
title_fullStr | The role of microbiota in the development of colorectal cancer |
title_full_unstemmed | The role of microbiota in the development of colorectal cancer |
title_short | The role of microbiota in the development of colorectal cancer |
title_sort | role of microbiota in the development of colorectal cancer |
topic | Mini Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899977/ https://www.ncbi.nlm.nih.gov/pubmed/30474116 http://dx.doi.org/10.1002/ijc.32017 |
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