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GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor...

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Autores principales: Walther, Barbara, Lett, Aaron M., Bordoni, Alessandra, Tomás‐Cobos, Lidia, Nieto, Juan Antonio, Dupont, Didier, Danesi, Francesca, Shahar, Danit R., Echaniz, Ana, Re, Roberta, Fernandez, Aida Sainz, Deglaire, Amélie, Gille, Doreen, Schmid, Alexandra, Vergères, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900003/
https://www.ncbi.nlm.nih.gov/pubmed/31483113
http://dx.doi.org/10.1002/mnfr.201900677
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author Walther, Barbara
Lett, Aaron M.
Bordoni, Alessandra
Tomás‐Cobos, Lidia
Nieto, Juan Antonio
Dupont, Didier
Danesi, Francesca
Shahar, Danit R.
Echaniz, Ana
Re, Roberta
Fernandez, Aida Sainz
Deglaire, Amélie
Gille, Doreen
Schmid, Alexandra
Vergères, Guy
author_facet Walther, Barbara
Lett, Aaron M.
Bordoni, Alessandra
Tomás‐Cobos, Lidia
Nieto, Juan Antonio
Dupont, Didier
Danesi, Francesca
Shahar, Danit R.
Echaniz, Ana
Re, Roberta
Fernandez, Aida Sainz
Deglaire, Amélie
Gille, Doreen
Schmid, Alexandra
Vergères, Guy
author_sort Walther, Barbara
collection PubMed
description Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.
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spelling pubmed-69000032019-12-20 GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract Walther, Barbara Lett, Aaron M. Bordoni, Alessandra Tomás‐Cobos, Lidia Nieto, Juan Antonio Dupont, Didier Danesi, Francesca Shahar, Danit R. Echaniz, Ana Re, Roberta Fernandez, Aida Sainz Deglaire, Amélie Gille, Doreen Schmid, Alexandra Vergères, Guy Mol Nutr Food Res Review Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods. John Wiley and Sons Inc. 2019-10-01 2019-11 /pmc/articles/PMC6900003/ /pubmed/31483113 http://dx.doi.org/10.1002/mnfr.201900677 Text en © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Walther, Barbara
Lett, Aaron M.
Bordoni, Alessandra
Tomás‐Cobos, Lidia
Nieto, Juan Antonio
Dupont, Didier
Danesi, Francesca
Shahar, Danit R.
Echaniz, Ana
Re, Roberta
Fernandez, Aida Sainz
Deglaire, Amélie
Gille, Doreen
Schmid, Alexandra
Vergères, Guy
GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title_full GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title_fullStr GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title_full_unstemmed GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title_short GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
title_sort gutself: interindividual variability in the processing of dietary compounds by the human gastrointestinal tract
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900003/
https://www.ncbi.nlm.nih.gov/pubmed/31483113
http://dx.doi.org/10.1002/mnfr.201900677
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