Constrained Peptides with Fine‐Tuned Flexibility Inhibit NF‐Y Transcription Factor Assembly

Protein complex formation depends on the interplay between preorganization and flexibility of the binding epitopes involved. The design of epitope mimetics typically focuses on stabilizing a particular bioactive conformation, often without considering conformational dynamics, which limits the potent...

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Detalles Bibliográficos
Autores principales: Jeganathan, Sadasivam, Wendt, Mathias, Kiehstaller, Sebastian, Brancaccio, Diego, Kuepper, Arne, Pospiech, Nicole, Carotenuto, Alfonso, Novellino, Ettore, Hennig, Sven, Grossmann, Tom N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900064/
https://www.ncbi.nlm.nih.gov/pubmed/31539186
http://dx.doi.org/10.1002/anie.201907901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900064/
https://www.ncbi.nlm.nih.gov/pubmed/31539186
http://dx.doi.org/10.1002/anie.201907901

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