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Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres

Although DNA nanotechnology has developed into a highly innovative and lively field of research at the interface between chemistry, materials science, and biotechnology, there is still a great need for methodological approaches for bridging the size regime of DNA nanostructures with that of micromet...

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Autores principales: Hu, Yong, Grösche, Maximilian, Sheshachala, Sahana, Oelschlaeger, Claude, Willenbacher, Norbert, Rabe, Kersten S., Niemeyer, Christof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900086/
https://www.ncbi.nlm.nih.gov/pubmed/31625665
http://dx.doi.org/10.1002/anie.201910606
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author Hu, Yong
Grösche, Maximilian
Sheshachala, Sahana
Oelschlaeger, Claude
Willenbacher, Norbert
Rabe, Kersten S.
Niemeyer, Christof M.
author_facet Hu, Yong
Grösche, Maximilian
Sheshachala, Sahana
Oelschlaeger, Claude
Willenbacher, Norbert
Rabe, Kersten S.
Niemeyer, Christof M.
author_sort Hu, Yong
collection PubMed
description Although DNA nanotechnology has developed into a highly innovative and lively field of research at the interface between chemistry, materials science, and biotechnology, there is still a great need for methodological approaches for bridging the size regime of DNA nanostructures with that of micrometer‐ and millimeter‐sized units for practical applications. We report on novel hierarchically structured composite materials from silica nanoparticles and DNA polymers that can be obtained by self‐assembly through the clamped hybridization chain reaction. The nanocomposite materials can be assembled into thin layers within microfluidically generated water‐in‐oil droplets to produce mechanically stabilized hollow spheres with uniform size distributions at high throughput rates. The fact that cells can be encapsulated in these microcontainers suggests that our concept not only contributes to the further development of supramolecular bottom‐up manufacturing, but can also be exploited for applications in the life sciences.
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spelling pubmed-69000862019-12-20 Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres Hu, Yong Grösche, Maximilian Sheshachala, Sahana Oelschlaeger, Claude Willenbacher, Norbert Rabe, Kersten S. Niemeyer, Christof M. Angew Chem Int Ed Engl Communications Although DNA nanotechnology has developed into a highly innovative and lively field of research at the interface between chemistry, materials science, and biotechnology, there is still a great need for methodological approaches for bridging the size regime of DNA nanostructures with that of micrometer‐ and millimeter‐sized units for practical applications. We report on novel hierarchically structured composite materials from silica nanoparticles and DNA polymers that can be obtained by self‐assembly through the clamped hybridization chain reaction. The nanocomposite materials can be assembled into thin layers within microfluidically generated water‐in‐oil droplets to produce mechanically stabilized hollow spheres with uniform size distributions at high throughput rates. The fact that cells can be encapsulated in these microcontainers suggests that our concept not only contributes to the further development of supramolecular bottom‐up manufacturing, but can also be exploited for applications in the life sciences. John Wiley and Sons Inc. 2019-10-18 2019-11-25 /pmc/articles/PMC6900086/ /pubmed/31625665 http://dx.doi.org/10.1002/anie.201910606 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Hu, Yong
Grösche, Maximilian
Sheshachala, Sahana
Oelschlaeger, Claude
Willenbacher, Norbert
Rabe, Kersten S.
Niemeyer, Christof M.
Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title_full Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title_fullStr Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title_full_unstemmed Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title_short Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
title_sort bottom‐up assembly of dna–silica nanocomposites into micrometer‐sized hollow spheres
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900086/
https://www.ncbi.nlm.nih.gov/pubmed/31625665
http://dx.doi.org/10.1002/anie.201910606
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