Cargando…
Repetitive Saliva Swallowing Test Predicts COPD Exacerbation
INTRODUCTION: Predicting phenotypes at risk of chronic obstructive pulmonary disease (COPD) exacerbation is extremely important. Dysphagia is becoming recognized as one of these phenotypes. A convenient method of screening for dysphagia and COPD exacerbation risk is desired. The repetitive saliva sw...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900275/ https://www.ncbi.nlm.nih.gov/pubmed/31824143 http://dx.doi.org/10.2147/COPD.S226268 |
_version_ | 1783477321120874496 |
---|---|
author | Yoshimatsu, Yuki Tobino, Kazunori Sueyasu, Takuto Nishizawa, Saori Ko, Yuki Yasuda, Mina Ide, Hiromi Tsuruno, Kosuke Miyajima, Hiroyuki |
author_facet | Yoshimatsu, Yuki Tobino, Kazunori Sueyasu, Takuto Nishizawa, Saori Ko, Yuki Yasuda, Mina Ide, Hiromi Tsuruno, Kosuke Miyajima, Hiroyuki |
author_sort | Yoshimatsu, Yuki |
collection | PubMed |
description | INTRODUCTION: Predicting phenotypes at risk of chronic obstructive pulmonary disease (COPD) exacerbation is extremely important. Dysphagia is becoming recognized as one of these phenotypes. A convenient method of screening for dysphagia and COPD exacerbation risk is desired. The repetitive saliva swallowing test (RSST) is one of the least invasive dysphagia screening methods. We previously reported the possible relation between the RSST result and COPD exacerbation in a retrospective study. Based on this, we performed a prospective study to evaluate the efficacy of RSST as a predictor of COPD exacerbation and to determine its optimal cut-off value for COPD. METHODS: Seventy patients with COPD were recruited. Patients underwent the following dysphagia screening tests: the 10-item Eating Assessment Tool, Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease, RSST, water swallowing test, and simple swallow provocation test. After one year, they were classified into two groups according to the presence of COPD exacerbation during the follow-up period. RESULTS: Twenty-seven patients had one or more exacerbations in the past year. During the follow-up period, 28 patients had one or more exacerbations (E group), and 42 had none (non-E group). There were no significant differences between the groups except for the presence of past exacerbations and the results of the RSST, when the cut-off value was set at 2, 3, 4, or 5 swallows. The number of swallows in the RSST was significantly lower in the E group than in the Non-E group. A cut-off value of 5 was the most effective. The time to first exacerbation was significantly longer in those with an RSST value of >5. The RSST was more reliable for differentiating the E group and non-E group than the presence of exacerbation in the past year (hazard ratios: 13.78 and 2.70, respectively). CONCLUSION: An RSST cut-off value of 5 may be a strong predictor of COPD exacerbation. |
format | Online Article Text |
id | pubmed-6900275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-69002752019-12-10 Repetitive Saliva Swallowing Test Predicts COPD Exacerbation Yoshimatsu, Yuki Tobino, Kazunori Sueyasu, Takuto Nishizawa, Saori Ko, Yuki Yasuda, Mina Ide, Hiromi Tsuruno, Kosuke Miyajima, Hiroyuki Int J Chron Obstruct Pulmon Dis Original Research INTRODUCTION: Predicting phenotypes at risk of chronic obstructive pulmonary disease (COPD) exacerbation is extremely important. Dysphagia is becoming recognized as one of these phenotypes. A convenient method of screening for dysphagia and COPD exacerbation risk is desired. The repetitive saliva swallowing test (RSST) is one of the least invasive dysphagia screening methods. We previously reported the possible relation between the RSST result and COPD exacerbation in a retrospective study. Based on this, we performed a prospective study to evaluate the efficacy of RSST as a predictor of COPD exacerbation and to determine its optimal cut-off value for COPD. METHODS: Seventy patients with COPD were recruited. Patients underwent the following dysphagia screening tests: the 10-item Eating Assessment Tool, Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease, RSST, water swallowing test, and simple swallow provocation test. After one year, they were classified into two groups according to the presence of COPD exacerbation during the follow-up period. RESULTS: Twenty-seven patients had one or more exacerbations in the past year. During the follow-up period, 28 patients had one or more exacerbations (E group), and 42 had none (non-E group). There were no significant differences between the groups except for the presence of past exacerbations and the results of the RSST, when the cut-off value was set at 2, 3, 4, or 5 swallows. The number of swallows in the RSST was significantly lower in the E group than in the Non-E group. A cut-off value of 5 was the most effective. The time to first exacerbation was significantly longer in those with an RSST value of >5. The RSST was more reliable for differentiating the E group and non-E group than the presence of exacerbation in the past year (hazard ratios: 13.78 and 2.70, respectively). CONCLUSION: An RSST cut-off value of 5 may be a strong predictor of COPD exacerbation. Dove 2019-12-04 /pmc/articles/PMC6900275/ /pubmed/31824143 http://dx.doi.org/10.2147/COPD.S226268 Text en © 2019 Yoshimatsu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Yoshimatsu, Yuki Tobino, Kazunori Sueyasu, Takuto Nishizawa, Saori Ko, Yuki Yasuda, Mina Ide, Hiromi Tsuruno, Kosuke Miyajima, Hiroyuki Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title | Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title_full | Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title_fullStr | Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title_full_unstemmed | Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title_short | Repetitive Saliva Swallowing Test Predicts COPD Exacerbation |
title_sort | repetitive saliva swallowing test predicts copd exacerbation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900275/ https://www.ncbi.nlm.nih.gov/pubmed/31824143 http://dx.doi.org/10.2147/COPD.S226268 |
work_keys_str_mv | AT yoshimatsuyuki repetitivesalivaswallowingtestpredictscopdexacerbation AT tobinokazunori repetitivesalivaswallowingtestpredictscopdexacerbation AT sueyasutakuto repetitivesalivaswallowingtestpredictscopdexacerbation AT nishizawasaori repetitivesalivaswallowingtestpredictscopdexacerbation AT koyuki repetitivesalivaswallowingtestpredictscopdexacerbation AT yasudamina repetitivesalivaswallowingtestpredictscopdexacerbation AT idehiromi repetitivesalivaswallowingtestpredictscopdexacerbation AT tsurunokosuke repetitivesalivaswallowingtestpredictscopdexacerbation AT miyajimahiroyuki repetitivesalivaswallowingtestpredictscopdexacerbation |