Cargando…

The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

BACKGROUND: To better evaluate the efficacy of CoQ10 on the inflammatory markers in breast cancer patients, we conducted a clinical study of patients with breast cancer undergoing tamoxifen therapy. CoQ10 serves as an antioxidant and inhibits oxidation caused by reactive oxygen species. The aim of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zahrooni, Nazanin, Hosseini, Seyed Ahmad, Ahmadzadeh, Ahmad, Ahmadi Angali, Kambiz, Assarehzadegan, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900311/
https://www.ncbi.nlm.nih.gov/pubmed/31824163
http://dx.doi.org/10.2147/TCRM.S234930
_version_ 1783477329901649920
author Zahrooni, Nazanin
Hosseini, Seyed Ahmad
Ahmadzadeh, Ahmad
Ahmadi Angali, Kambiz
Assarehzadegan, Mohammad Ali
author_facet Zahrooni, Nazanin
Hosseini, Seyed Ahmad
Ahmadzadeh, Ahmad
Ahmadi Angali, Kambiz
Assarehzadegan, Mohammad Ali
author_sort Zahrooni, Nazanin
collection PubMed
description BACKGROUND: To better evaluate the efficacy of CoQ10 on the inflammatory markers in breast cancer patients, we conducted a clinical study of patients with breast cancer undergoing tamoxifen therapy. CoQ10 serves as an antioxidant and inhibits oxidation caused by reactive oxygen species. The aim of the current study was to assess the effect of coenzyme Q10 supplementation on serum levels of interleukin 6, 8, and vascular endothelial growth factor (VEGF) in patients with breast cancer undergoing tamoxifen therapy by a double-blind, placebo-controlled, randomized clinical trial. METHODS: In the study, 30 breast cancer patients and 29 healthy subjects were randomized into four groups. Two groups of intervention received 100 mg CoQ10, and two control groups took placebo once a day for 2 months. Blood draws were obtained at baseline and at the end of the study. Serum levels of IL-6, IL-8 and VEGF were analyzed using ELISA kits. RESULTS: The data of the 59 participants were analyzed. Supplementation with CoQ10 demonstrated a significant decrease in IL-8 and IL-6 serum levels compared to placebo (P< 0.05). Although the downward trend was evident, CoQ10 supplementation did not reveal any significant effect on serum VEGF concentration. The group of patients who received supplements showed the most reduction in serum levels of cytokines among other groups. CONCLUSION: CoQ10 supplementation could be effective in ameliorating inflammatory cytokine levels, thereby reducing the consequences of inflammation caused by breast cancer. To generalize the results, larger and longer intervention studies with higher safe doses are needed and should take account of possible costs and harms as well as benefits (registration number: IRCT2015042021874N1).
format Online
Article
Text
id pubmed-6900311
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-69003112019-12-10 The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial Zahrooni, Nazanin Hosseini, Seyed Ahmad Ahmadzadeh, Ahmad Ahmadi Angali, Kambiz Assarehzadegan, Mohammad Ali Ther Clin Risk Manag Original Research BACKGROUND: To better evaluate the efficacy of CoQ10 on the inflammatory markers in breast cancer patients, we conducted a clinical study of patients with breast cancer undergoing tamoxifen therapy. CoQ10 serves as an antioxidant and inhibits oxidation caused by reactive oxygen species. The aim of the current study was to assess the effect of coenzyme Q10 supplementation on serum levels of interleukin 6, 8, and vascular endothelial growth factor (VEGF) in patients with breast cancer undergoing tamoxifen therapy by a double-blind, placebo-controlled, randomized clinical trial. METHODS: In the study, 30 breast cancer patients and 29 healthy subjects were randomized into four groups. Two groups of intervention received 100 mg CoQ10, and two control groups took placebo once a day for 2 months. Blood draws were obtained at baseline and at the end of the study. Serum levels of IL-6, IL-8 and VEGF were analyzed using ELISA kits. RESULTS: The data of the 59 participants were analyzed. Supplementation with CoQ10 demonstrated a significant decrease in IL-8 and IL-6 serum levels compared to placebo (P< 0.05). Although the downward trend was evident, CoQ10 supplementation did not reveal any significant effect on serum VEGF concentration. The group of patients who received supplements showed the most reduction in serum levels of cytokines among other groups. CONCLUSION: CoQ10 supplementation could be effective in ameliorating inflammatory cytokine levels, thereby reducing the consequences of inflammation caused by breast cancer. To generalize the results, larger and longer intervention studies with higher safe doses are needed and should take account of possible costs and harms as well as benefits (registration number: IRCT2015042021874N1). Dove 2019-12-04 /pmc/articles/PMC6900311/ /pubmed/31824163 http://dx.doi.org/10.2147/TCRM.S234930 Text en © 2019 Zahrooni et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zahrooni, Nazanin
Hosseini, Seyed Ahmad
Ahmadzadeh, Ahmad
Ahmadi Angali, Kambiz
Assarehzadegan, Mohammad Ali
The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title_full The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title_fullStr The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title_full_unstemmed The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title_short The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial
title_sort effect of coenzyme q10 supplementation on vascular endothelial growth factor and serum levels of interleukin 6 and 8 in women with breast cancer: a double-blind, placebo-controlled, randomized clinical trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900311/
https://www.ncbi.nlm.nih.gov/pubmed/31824163
http://dx.doi.org/10.2147/TCRM.S234930
work_keys_str_mv AT zahrooninazanin theeffectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT hosseiniseyedahmad theeffectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT ahmadzadehahmad theeffectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT ahmadiangalikambiz theeffectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT assarehzadeganmohammadali theeffectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT zahrooninazanin effectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT hosseiniseyedahmad effectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT ahmadzadehahmad effectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT ahmadiangalikambiz effectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial
AT assarehzadeganmohammadali effectofcoenzymeq10supplementationonvascularendothelialgrowthfactorandserumlevelsofinterleukin6and8inwomenwithbreastcanceradoubleblindplacebocontrolledrandomizedclinicaltrial