Molecular docking analysis of zanamavir with haem agglutinin neuraminidase of human para influenza virus type 3

The human para influenza virus (HPIV) type 3 is an imperative respiratory virus which cause upper and lower respiratory infections. The receptor involved in the viral infection is haem agglutinin neuraminidase. It is of interest to study the interaction of haem agglutinin neuraminidase with zanamavi...

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Detalles Bibliográficos
Autores principales: Indumathi, Chinayan Palani, Bupesh, Giridharan, Vasanth, Sakthivel, Senthilkumar, Vijayan, Anandh, Arumugam Vijaya, Pandian, Kanniyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900320/
https://www.ncbi.nlm.nih.gov/pubmed/31831955
http://dx.doi.org/10.6026/97320630015730
Descripción
Sumario:The human para influenza virus (HPIV) type 3 is an imperative respiratory virus which cause upper and lower respiratory infections. The receptor involved in the viral infection is haem agglutinin neuraminidase. It is of interest to study the interaction of haem agglutinin neuraminidase with zanamavir (4-GU-DANA), a known antiviral drug. We used the PDB structures with PDB IDs 1V2I, 1V3B, 1V3D and 1V3E for studying the interactions with zanamavir. The binding features of zanamavir with 1V2I (1.41kcal/mol) and 1V3E (11.81kcal/mol) having optimal interactions is reported for further consideration.

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