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2,5-Hexanedione mediates neuronal apoptosis through suppression of NGF via PI3K/Akt signaling in the rat sciatic nerve

Because precise mechanism for 2,5-hexanedione (HD)-induced neuronal apoptosis largely remains unknown, we explored the potential mechanisms both in vivo and in vitro. Rats were intraperitoneally exposed to HD at different doses for 5 weeks, following which the expression levels of nerve growth facto...

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Detalles Bibliográficos
Autores principales:	Zuo, Enjun, Zhang, Cong, Mao, Jun, Gao, Chenxue, Hu, Shuhai, Shi, Xiaoxia, Piao, Fengyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Ecology & Environmental Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900430/ https://www.ncbi.nlm.nih.gov/pubmed/30670632 http://dx.doi.org/10.1042/BSR20181122

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