CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential

In mice, the ability of naive T (T(N)) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discre...

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Detalles Bibliográficos
Autores principales: De Simone, Gabriele, Mazza, Emilia M. C., Cassotta, Antonino, Davydov, Alexey N., Kuka, Mirela, Zanon, Veronica, De Paoli, Federica, Scamardella, Eloise, Metsger, Maria, Roberto, Alessandra, Pilipow, Karolina, Colombo, Federico S., Tenedini, Elena, Tagliafico, Enrico, Gattinoni, Luca, Mavilio, Domenico, Peano, Clelia, Price, David A., Singh, Satya P., Farber, Joshua M., Serra, Valentina, Cucca, Francesco, Ferrari, Francesco, Orrù, Valeria, Fiorillo, Edoardo, Iannacone, Matteo, Chudakov, Dmitriy M., Sallusto, Federica, Lugli, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2019
Materias:
Clinical and Human Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900484/
https://www.ncbi.nlm.nih.gov/pubmed/31740485
http://dx.doi.org/10.4049/jimmunol.1901072

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