The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

There has been a resurgence of interest in the volume‐regulated anion channel (VRAC) since the recent cloning of the LRRC8A‐E gene family that encodes VRAC. The channel is a heteromer comprised of LRRC8A and at least one other family member; disruption of LRRC8A expression abolishes VRAC activity. T...

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Detalles Bibliográficos
Autores principales: Afzal, Aqeela, Figueroa, Eric E., Kharade, Sujay V., Bittman, Kevin, Matlock, Brittany K., Flaherty, David K., Denton, Jerod S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900491/
https://www.ncbi.nlm.nih.gov/pubmed/31814333
http://dx.doi.org/10.14814/phy2.14303

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