Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Dependence on the 26S proteasome is an Achilles’ heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to drug-resistant disease relapse and fails in breast cancer. Here we show that a 26S pr...

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Detalles Bibliográficos
Autores principales: Banerjee, Sourav, Wei, Tiantian, Wang, Jue, Lee, Jenna J., Gutierrez, Haydee L., Chapman, Owen, Wiley, Sandra E., Mayfield, Joshua E., Tandon, Vasudha, Juarez, Edwin F., Chavez, Lukas, Liang, Ruqi, Sah, Robert L., Costello, Caitlin, Mesirov, Jill P., de la Vega, Laureano, Cooper, Kimberly L., Dixon, Jack E., Xiao, Junyu, Lei, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900511/
https://www.ncbi.nlm.nih.gov/pubmed/31754034
http://dx.doi.org/10.1073/pnas.1912033116

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