Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia

Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators may attenuate PCSK9-induced low-density lipoprotein receptor (LDLR) degradation in lysosome and promote the clearance of circulating low-density lipoprotein cholesterol (LDL-C). A novel series of tetrahydroprotoberberine derivatives (T...

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Detalles Bibliográficos
Autores principales: Wu, Chenglin, Xi, Cong, Tong, Junhua, Zhao, Jing, Jiang, Hualiang, Wang, Jiang, Wang, Yiping, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900552/
https://www.ncbi.nlm.nih.gov/pubmed/31867167
http://dx.doi.org/10.1016/j.apsb.2019.06.006

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