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Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy
Simplifying or switching antiretroviral therapy (ART) in treatment-experienced people living with HIV (PLWH) may improve adherence, tolerability, toxicities, and/or drug–drug interactions. The purpose of this review is to critically evaluate the literature for efficacy and safety associated with swi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900586/ https://www.ncbi.nlm.nih.gov/pubmed/31516088 http://dx.doi.org/10.1177/2325958219867325 |
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author | Chastain, Daniel Badowski, Melissa Huesgen, Emily Pandit, Neha Sheth Pallotta, Andrea Michienzi, Sarah |
author_facet | Chastain, Daniel Badowski, Melissa Huesgen, Emily Pandit, Neha Sheth Pallotta, Andrea Michienzi, Sarah |
author_sort | Chastain, Daniel |
collection | PubMed |
description | Simplifying or switching antiretroviral therapy (ART) in treatment-experienced people living with HIV (PLWH) may improve adherence, tolerability, toxicities, and/or drug–drug interactions. The purpose of this review is to critically evaluate the literature for efficacy and safety associated with switching or simplifying ART in treatment-experienced PLWH. A systematic literature search using MEDLINE was performed from January 1, 2010 to April 30, 2018. References within articles of interest, the Department of Health and Human Services guidelines, and conference abstracts were also reviewed. Switch/simplification strategies were categorized as those supported by high-level clinical evidence and those with emerging data. Rates of virologic suppression were noninferior for several switch/simplification strategies when compared to baseline ART. Potential for reducing adverse events was also seen. Additional evidence for some strategies, including most 2-drug regimens, is needed before they can be recommended. |
format | Online Article Text |
id | pubmed-6900586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-69005862019-12-12 Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy Chastain, Daniel Badowski, Melissa Huesgen, Emily Pandit, Neha Sheth Pallotta, Andrea Michienzi, Sarah J Int Assoc Provid AIDS Care Review Simplifying or switching antiretroviral therapy (ART) in treatment-experienced people living with HIV (PLWH) may improve adherence, tolerability, toxicities, and/or drug–drug interactions. The purpose of this review is to critically evaluate the literature for efficacy and safety associated with switching or simplifying ART in treatment-experienced PLWH. A systematic literature search using MEDLINE was performed from January 1, 2010 to April 30, 2018. References within articles of interest, the Department of Health and Human Services guidelines, and conference abstracts were also reviewed. Switch/simplification strategies were categorized as those supported by high-level clinical evidence and those with emerging data. Rates of virologic suppression were noninferior for several switch/simplification strategies when compared to baseline ART. Potential for reducing adverse events was also seen. Additional evidence for some strategies, including most 2-drug regimens, is needed before they can be recommended. SAGE Publications 2019-09-13 /pmc/articles/PMC6900586/ /pubmed/31516088 http://dx.doi.org/10.1177/2325958219867325 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Chastain, Daniel Badowski, Melissa Huesgen, Emily Pandit, Neha Sheth Pallotta, Andrea Michienzi, Sarah Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV Practice and Research Network of the American College of Clinical Pharmacy |
title | Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living
with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV
Practice and Research Network of the American College of Clinical Pharmacy |
title_full | Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living
with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV
Practice and Research Network of the American College of Clinical Pharmacy |
title_fullStr | Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living
with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV
Practice and Research Network of the American College of Clinical Pharmacy |
title_full_unstemmed | Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living
with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV
Practice and Research Network of the American College of Clinical Pharmacy |
title_short | Optimizing Antiretroviral Therapy in Treatment-Experienced Patients Living
with HIV: A Critical Review of Switch and Simplification Strategies. An Opinion of the HIV
Practice and Research Network of the American College of Clinical Pharmacy |
title_sort | optimizing antiretroviral therapy in treatment-experienced patients living
with hiv: a critical review of switch and simplification strategies. an opinion of the hiv
practice and research network of the american college of clinical pharmacy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900586/ https://www.ncbi.nlm.nih.gov/pubmed/31516088 http://dx.doi.org/10.1177/2325958219867325 |
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