PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection

Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4(+) T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Althou...

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Detalles Bibliográficos
Autores principales: Crakes, Katti R., Santos Rocha, Clarissa, Grishina, Irina, Hirao, Lauren A., Napoli, Eleonora, Gaulke, Christopher A., Fenton, Anne, Datta, Sandipan, Arredondo, Juan, Marco, Maria L., Sankaran-Walters, Sumathi, Cortopassi, Gino, Giulivi, Cecilia, Dandekar, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900595/
https://www.ncbi.nlm.nih.gov/pubmed/31740620
http://dx.doi.org/10.1073/pnas.1908977116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900595/
https://www.ncbi.nlm.nih.gov/pubmed/31740620
http://dx.doi.org/10.1073/pnas.1908977116

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