De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course

The gastrointestinal tract is a common extranodal site for lymphomas. However, primary gastrointestinal lymphomas are rare. Diffuse large B-cell lymphomas (DLBCL) are the most commonly encountered type in the gastrointestinal tract. Most of the DLBCL are CD5 negative. CD5+ DLBCL is very rare and a p...

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Detalles Bibliográficos
Autores principales: Ramachandran, Preethi, Sahni, Sonu, Wang, Jen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900610/
https://www.ncbi.nlm.nih.gov/pubmed/31814435
http://dx.doi.org/10.1177/2324709619893546
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author Ramachandran, Preethi
Sahni, Sonu
Wang, Jen C.
author_facet Ramachandran, Preethi
Sahni, Sonu
Wang, Jen C.
author_sort Ramachandran, Preethi
collection PubMed
description The gastrointestinal tract is a common extranodal site for lymphomas. However, primary gastrointestinal lymphomas are rare. Diffuse large B-cell lymphomas (DLBCL) are the most commonly encountered type in the gastrointestinal tract. Most of the DLBCL are CD5 negative. CD5+ DLBCL is very rare and a poor prognostic subtype of lymphoma. We report a rare case of primary small bowel CD5+ DLBCL that evolved from being a localized low International Prognostic Index–scored disease into an advanced and aggressive disease primarily dictated by the presence of CD5 antigen positivity.
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spelling pubmed-69006102019-12-13 De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course Ramachandran, Preethi Sahni, Sonu Wang, Jen C. J Investig Med High Impact Case Rep Case Report The gastrointestinal tract is a common extranodal site for lymphomas. However, primary gastrointestinal lymphomas are rare. Diffuse large B-cell lymphomas (DLBCL) are the most commonly encountered type in the gastrointestinal tract. Most of the DLBCL are CD5 negative. CD5+ DLBCL is very rare and a poor prognostic subtype of lymphoma. We report a rare case of primary small bowel CD5+ DLBCL that evolved from being a localized low International Prognostic Index–scored disease into an advanced and aggressive disease primarily dictated by the presence of CD5 antigen positivity. SAGE Publications 2019-12-07 /pmc/articles/PMC6900610/ /pubmed/31814435 http://dx.doi.org/10.1177/2324709619893546 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Ramachandran, Preethi
Sahni, Sonu
Wang, Jen C.
De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title_full De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title_fullStr De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title_full_unstemmed De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title_short De Novo CD5+ Primary Gastrointestinal Diffuse Large B-Cell Lymphoma: Challenges With Treatment and Clinical Course
title_sort de novo cd5+ primary gastrointestinal diffuse large b-cell lymphoma: challenges with treatment and clinical course
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900610/
https://www.ncbi.nlm.nih.gov/pubmed/31814435
http://dx.doi.org/10.1177/2324709619893546
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AT wangjenc denovocd5primarygastrointestinaldiffuselargebcelllymphomachallengeswithtreatmentandclinicalcourse

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