High serum concentration of vitamin D may protect against multiple sclerosis

BACKGROUND: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. OBJECTIVE: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age de...

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Detalles Bibliográficos
Autores principales: Biström, Martin, Alonso-Magdalena, Lucia, Andersen, Oluf, Jons, Daniel, Gunnarsson, Martin, Vrethem, Magnus, Hultdin, Johan, Sundström, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900627/
https://www.ncbi.nlm.nih.gov/pubmed/31839980
http://dx.doi.org/10.1177/2055217319892291
Descripción
Sumario:BACKGROUND: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. OBJECTIVE: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent. METHODS: Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry. RESULTS: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93). CONCLUSION: These findings further support a role for vitamin D in MS aetiology.

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