High serum concentration of vitamin D may protect against multiple sclerosis

BACKGROUND: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. OBJECTIVE: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age de...

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Autores principales: Biström, Martin, Alonso-Magdalena, Lucia, Andersen, Oluf, Jons, Daniel, Gunnarsson, Martin, Vrethem, Magnus, Hultdin, Johan, Sundström, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900627/
https://www.ncbi.nlm.nih.gov/pubmed/31839980
http://dx.doi.org/10.1177/2055217319892291
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author Biström, Martin
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
author_facet Biström, Martin
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
author_sort Biström, Martin
collection PubMed
description BACKGROUND: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. OBJECTIVE: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent. METHODS: Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry. RESULTS: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93). CONCLUSION: These findings further support a role for vitamin D in MS aetiology.
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spelling pubmed-69006272019-12-13 High serum concentration of vitamin D may protect against multiple sclerosis Biström, Martin Alonso-Magdalena, Lucia Andersen, Oluf Jons, Daniel Gunnarsson, Martin Vrethem, Magnus Hultdin, Johan Sundström, Peter Mult Scler J Exp Transl Clin Short Report BACKGROUND: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals. OBJECTIVE: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent. METHODS: Prospectively drawn blood samples from individuals later developing relapsing–remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry. RESULTS: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50–0.93). CONCLUSION: These findings further support a role for vitamin D in MS aetiology. SAGE Publications 2019-12-06 /pmc/articles/PMC6900627/ /pubmed/31839980 http://dx.doi.org/10.1177/2055217319892291 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/ Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Short Report
Biström, Martin
Alonso-Magdalena, Lucia
Andersen, Oluf
Jons, Daniel
Gunnarsson, Martin
Vrethem, Magnus
Hultdin, Johan
Sundström, Peter
High serum concentration of vitamin D may protect against multiple sclerosis
title High serum concentration of vitamin D may protect against multiple sclerosis
title_full High serum concentration of vitamin D may protect against multiple sclerosis
title_fullStr High serum concentration of vitamin D may protect against multiple sclerosis
title_full_unstemmed High serum concentration of vitamin D may protect against multiple sclerosis
title_short High serum concentration of vitamin D may protect against multiple sclerosis
title_sort high serum concentration of vitamin d may protect against multiple sclerosis
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900627/
https://www.ncbi.nlm.nih.gov/pubmed/31839980
http://dx.doi.org/10.1177/2055217319892291
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