Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection

Human TLR4 (hTLR4) and mouse TLR4 molecules respond differently to hypo-acylated LPS. The LPS of Coxiella burnetii is hypo-acylated and heavily glycosylated and causes a minimal response by human cells. Thus, we hypothesized that mice expressing hTLR4 molecules would be more susceptible to C. burnet...

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Detalles Bibliográficos
Autores principales: Robison, Amanda, Snyder, Deann T, Christensen, Kelly, Kimmel, Emily, Hajjar, Adeline M, Jutila, Mark A, Hedges, Jodi F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900644/
https://www.ncbi.nlm.nih.gov/pubmed/31180798
http://dx.doi.org/10.1177/1753425919855420

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