Cargando…

Association between IL-6 polymorphisms and sepsis

The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were include...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Peiyang, Chen, Yimin, Pang, Jianliang, Chen, Xionghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900662/
https://www.ncbi.nlm.nih.gov/pubmed/31474166
http://dx.doi.org/10.1177/1753425919872818
_version_ 1783477389391560704
author Hu, Peiyang
Chen, Yimin
Pang, Jianliang
Chen, Xionghuan
author_facet Hu, Peiyang
Chen, Yimin
Pang, Jianliang
Chen, Xionghuan
author_sort Hu, Peiyang
collection PubMed
description The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were included in this meta-analysis. There was no significant association between the IL-6-174G/C polymorphism and sepsis risk in the total population (C vs. G: OR = 1.04, 95% CI = 0.79–1.38; CC vs. GG: OR = 0.86, 95% CI = 0.53–1.41; CG vs. GG: OR = 0.99, 95% CI = 0.79–1.24; dominant model: OR = 0.97, 95% CI = 0.74–1.29; recessive model: OR = 0.92, 95% CI = 0.61–1.39). When patients were stratified according to ethnicity, a statistically significant association was observed in Asians and Africans. As for the -572G/C polymorphism, the results showed that the IL-6-572C/G polymorphism was not associated with sepsis susceptibility (G vs. C: OR = 0.98, 95% CI = 0.79–1.22; GG vs. CC: OR = 1.46, 95% CI = 0.53–4.03; GC vs. CC: OR = 0.82, 95% CI = 0.54–1.27; dominant model: OR = 0.88, 95% CI = 0.55–1.41; recessive model: OR = 1.55, 95% CI = 0.82–2.92). The data indicated that the IL-6-174G/C polymorphism may contribute to sepsis risk, especially in Africans and Asians. No significant association was observed between the IL-6-572G/C polymorphism and sepsis risk.
format Online
Article
Text
id pubmed-6900662
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-69006622019-12-13 Association between IL-6 polymorphisms and sepsis Hu, Peiyang Chen, Yimin Pang, Jianliang Chen, Xionghuan Innate Immun Original Articles The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were included in this meta-analysis. There was no significant association between the IL-6-174G/C polymorphism and sepsis risk in the total population (C vs. G: OR = 1.04, 95% CI = 0.79–1.38; CC vs. GG: OR = 0.86, 95% CI = 0.53–1.41; CG vs. GG: OR = 0.99, 95% CI = 0.79–1.24; dominant model: OR = 0.97, 95% CI = 0.74–1.29; recessive model: OR = 0.92, 95% CI = 0.61–1.39). When patients were stratified according to ethnicity, a statistically significant association was observed in Asians and Africans. As for the -572G/C polymorphism, the results showed that the IL-6-572C/G polymorphism was not associated with sepsis susceptibility (G vs. C: OR = 0.98, 95% CI = 0.79–1.22; GG vs. CC: OR = 1.46, 95% CI = 0.53–4.03; GC vs. CC: OR = 0.82, 95% CI = 0.54–1.27; dominant model: OR = 0.88, 95% CI = 0.55–1.41; recessive model: OR = 1.55, 95% CI = 0.82–2.92). The data indicated that the IL-6-174G/C polymorphism may contribute to sepsis risk, especially in Africans and Asians. No significant association was observed between the IL-6-572G/C polymorphism and sepsis risk. SAGE Publications 2019-08-31 2019-11 /pmc/articles/PMC6900662/ /pubmed/31474166 http://dx.doi.org/10.1177/1753425919872818 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Hu, Peiyang
Chen, Yimin
Pang, Jianliang
Chen, Xionghuan
Association between IL-6 polymorphisms and sepsis
title Association between IL-6 polymorphisms and sepsis
title_full Association between IL-6 polymorphisms and sepsis
title_fullStr Association between IL-6 polymorphisms and sepsis
title_full_unstemmed Association between IL-6 polymorphisms and sepsis
title_short Association between IL-6 polymorphisms and sepsis
title_sort association between il-6 polymorphisms and sepsis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900662/
https://www.ncbi.nlm.nih.gov/pubmed/31474166
http://dx.doi.org/10.1177/1753425919872818
work_keys_str_mv AT hupeiyang associationbetweenil6polymorphismsandsepsis
AT chenyimin associationbetweenil6polymorphismsandsepsis
AT pangjianliang associationbetweenil6polymorphismsandsepsis
AT chenxionghuan associationbetweenil6polymorphismsandsepsis