ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection

Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC expansion in response to infection. We find that infection by Gram-negative bacteria drives an increase in mitochondrial mass in mammalian HS...

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Detalles Bibliográficos
Autores principales: Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900710/
https://www.ncbi.nlm.nih.gov/pubmed/31727843
http://dx.doi.org/10.1073/pnas.1913278116

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