A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO(−) over other reactive oxygen species, including H(2)O(2). Moreover, DCM‐Bpin is biocompatible a...

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Detalles Bibliográficos
Autores principales: Wu, Luling, Tian, Xue, Han, Hai‐Hao, Wang, Jie, Groleau, Robin R., Tosuwan, Paramabhorn, Wannalerse, Boontana, Sedgwick, Adam C., Bull, Steven D., He, Xiao‐Peng, James, Tony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900745/
https://www.ncbi.nlm.nih.gov/pubmed/31867147
http://dx.doi.org/10.1002/open.201900301
Descripción
Sumario:Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO(−) over other reactive oxygen species, including H(2)O(2). Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO(−) in HeLa cells.

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