A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO(−) over other reactive oxygen species, including H(2)O(2). Moreover, DCM‐Bpin is biocompatible a...

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Detalles Bibliográficos
Autores principales: Wu, Luling, Tian, Xue, Han, Hai‐Hao, Wang, Jie, Groleau, Robin R., Tosuwan, Paramabhorn, Wannalerse, Boontana, Sedgwick, Adam C., Bull, Steven D., He, Xiao‐Peng, James, Tony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900745/
https://www.ncbi.nlm.nih.gov/pubmed/31867147
http://dx.doi.org/10.1002/open.201900301
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author Wu, Luling
Tian, Xue
Han, Hai‐Hao
Wang, Jie
Groleau, Robin R.
Tosuwan, Paramabhorn
Wannalerse, Boontana
Sedgwick, Adam C.
Bull, Steven D.
He, Xiao‐Peng
James, Tony D.
author_facet Wu, Luling
Tian, Xue
Han, Hai‐Hao
Wang, Jie
Groleau, Robin R.
Tosuwan, Paramabhorn
Wannalerse, Boontana
Sedgwick, Adam C.
Bull, Steven D.
He, Xiao‐Peng
James, Tony D.
author_sort Wu, Luling
collection PubMed
description Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO(−) over other reactive oxygen species, including H(2)O(2). Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO(−) in HeLa cells.
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spelling pubmed-69007452019-12-20 A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite Wu, Luling Tian, Xue Han, Hai‐Hao Wang, Jie Groleau, Robin R. Tosuwan, Paramabhorn Wannalerse, Boontana Sedgwick, Adam C. Bull, Steven D. He, Xiao‐Peng James, Tony D. ChemistryOpen Communications Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM‐Bpin for the detection of Peroxynitrite (ONOO−). DCM‐Bpin exhibits selective fluorescence off‐on response for ONOO(−) over other reactive oxygen species, including H(2)O(2). Moreover, DCM‐Bpin is biocompatible and has been used to visualize exogenous ONOO(−) in HeLa cells. John Wiley and Sons Inc. 2019-12-09 /pmc/articles/PMC6900745/ /pubmed/31867147 http://dx.doi.org/10.1002/open.201900301 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Wu, Luling
Tian, Xue
Han, Hai‐Hao
Wang, Jie
Groleau, Robin R.
Tosuwan, Paramabhorn
Wannalerse, Boontana
Sedgwick, Adam C.
Bull, Steven D.
He, Xiao‐Peng
James, Tony D.
A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title_full A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title_fullStr A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title_full_unstemmed A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title_short A Simple Near‐Infrared Fluorescent Probe for the Detection of Peroxynitrite
title_sort simple near‐infrared fluorescent probe for the detection of peroxynitrite
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900745/
https://www.ncbi.nlm.nih.gov/pubmed/31867147
http://dx.doi.org/10.1002/open.201900301
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