The majority of A-to-I RNA editing is not required for mammalian homeostasis

BACKGROUND: Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes. A-to-I editing can change the protein coding potential of a transcript and alter RNA splicing, miRNA biology, RNA secondary structure...

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Detalles Bibliográficos
Autores principales: Chalk, Alistair M., Taylor, Scott, Heraud-Farlow, Jacki E., Walkley, Carl R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900863/
https://www.ncbi.nlm.nih.gov/pubmed/31815657
http://dx.doi.org/10.1186/s13059-019-1873-2

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