Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome

Congenital central hypoventilation syndrome (CCHS) is characterized by shallow breathing during sleep due to negligible ventilatory sensitivity to hypercarbia and hypoxemia. It is diagnosed using a genetic test for PHOX2B mutation, which is not easily available. Neurally adjusted ventilatory assist...

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Autores principales: Rauf, Abdul, Gupta, Dhiren, Sachdev, Anil, Gupta, Neeraj, Gupta, Suresh, Kumar, Praveen, Sabharwal, Ramakant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900881/
https://www.ncbi.nlm.nih.gov/pubmed/31911748
http://dx.doi.org/10.5005/jp-journals-10071-23286
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author Rauf, Abdul
Gupta, Dhiren
Sachdev, Anil
Gupta, Neeraj
Gupta, Suresh
Kumar, Praveen
Sabharwal, Ramakant
author_facet Rauf, Abdul
Gupta, Dhiren
Sachdev, Anil
Gupta, Neeraj
Gupta, Suresh
Kumar, Praveen
Sabharwal, Ramakant
author_sort Rauf, Abdul
collection PubMed
description Congenital central hypoventilation syndrome (CCHS) is characterized by shallow breathing during sleep due to negligible ventilatory sensitivity to hypercarbia and hypoxemia. It is diagnosed using a genetic test for PHOX2B mutation, which is not easily available. Neurally adjusted ventilatory assist (NAVA) is a spontaneous ventilatory mode that was designed basically for better adapting the ventilator to the patient by using electrical activity of diaphragm (EAdi) signals. We report a case of a 6-month-old infant who presented with recurrent apneas, where differential decrease in EAdi discharges during sleep using NAVA served as an early clue to the diagnosis of CCHS. Definitive diagnosis was later confirmed by genetic testing. HOW TO CITE THIS ARTICLE: Rauf A, Gupta D, Sachdev A, Gupta N, Gupta S, Kumar P, et al. Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome. IJCCM 2019;23(11):536–537.
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spelling pubmed-69008812020-01-07 Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome Rauf, Abdul Gupta, Dhiren Sachdev, Anil Gupta, Neeraj Gupta, Suresh Kumar, Praveen Sabharwal, Ramakant Indian J Crit Care Med Case Report Congenital central hypoventilation syndrome (CCHS) is characterized by shallow breathing during sleep due to negligible ventilatory sensitivity to hypercarbia and hypoxemia. It is diagnosed using a genetic test for PHOX2B mutation, which is not easily available. Neurally adjusted ventilatory assist (NAVA) is a spontaneous ventilatory mode that was designed basically for better adapting the ventilator to the patient by using electrical activity of diaphragm (EAdi) signals. We report a case of a 6-month-old infant who presented with recurrent apneas, where differential decrease in EAdi discharges during sleep using NAVA served as an early clue to the diagnosis of CCHS. Definitive diagnosis was later confirmed by genetic testing. HOW TO CITE THIS ARTICLE: Rauf A, Gupta D, Sachdev A, Gupta N, Gupta S, Kumar P, et al. Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome. IJCCM 2019;23(11):536–537. Jaypee Brothers Medical Publishers 2019-11 /pmc/articles/PMC6900881/ /pubmed/31911748 http://dx.doi.org/10.5005/jp-journals-10071-23286 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Rauf, Abdul
Gupta, Dhiren
Sachdev, Anil
Gupta, Neeraj
Gupta, Suresh
Kumar, Praveen
Sabharwal, Ramakant
Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title_full Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title_fullStr Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title_full_unstemmed Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title_short Neurally Adjusted Ventilatory Assist: An Early Clue to Diagnosis of Congenital Central Hypoventilation Syndrome
title_sort neurally adjusted ventilatory assist: an early clue to diagnosis of congenital central hypoventilation syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900881/
https://www.ncbi.nlm.nih.gov/pubmed/31911748
http://dx.doi.org/10.5005/jp-journals-10071-23286
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