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Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army
AIM: To analyze the effects of subcutaneous or intravenous rituximab + lymphokine-activated killer cells, obinutuzumab or ibrutinib on natural killer (NK) cell levels in chronic lymphocytic leukemia and follicular lymphoma patients. PATIENTS & METHODS: The distribution of peripheral blood NK cel...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Future Science Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900973/ https://www.ncbi.nlm.nih.gov/pubmed/31827894 http://dx.doi.org/10.2144/fsoa-2019-0064 |
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| author | García-Muñoz, Ricardo Nájera, María-Josefa Feliu, Jesús Antón-Remírez, Judith Ramalle-Gómara, Enrique Marín-Gorricho, Raquel Peralta, Raisa Gutiérrez-Gamarra, Elena Nuñez-Rodriguez, Jessica Zafra-Morales, Ricardo Aguinaga, Lorea Nebot-Villacampa, María-Jose Hernandez-Pérez, Prisma-Monserrat Farfán-Quiroga, Giovanna Panizo, Carlos Domínguez-Garrido, Elena |
| author_facet | García-Muñoz, Ricardo Nájera, María-Josefa Feliu, Jesús Antón-Remírez, Judith Ramalle-Gómara, Enrique Marín-Gorricho, Raquel Peralta, Raisa Gutiérrez-Gamarra, Elena Nuñez-Rodriguez, Jessica Zafra-Morales, Ricardo Aguinaga, Lorea Nebot-Villacampa, María-Jose Hernandez-Pérez, Prisma-Monserrat Farfán-Quiroga, Giovanna Panizo, Carlos Domínguez-Garrido, Elena |
| author_sort | García-Muñoz, Ricardo |
| collection | PubMed |
| description | AIM: To analyze the effects of subcutaneous or intravenous rituximab + lymphokine-activated killer cells, obinutuzumab or ibrutinib on natural killer (NK) cell levels in chronic lymphocytic leukemia and follicular lymphoma patients. PATIENTS & METHODS: The distribution of peripheral blood NK cells of 31 patients was analyzed by flow cytometry. RESULTS: We detected a decrease of NK cells in peripheral blood below normal range after obinutuzumab treatment. During maintenance treatment with subcutaneous rituximab, an NK cell reduction was less pronounced than after intravenous rituximab treatment, despite lymphokine-activated killer cell infusions. CONCLUSION: After one dose of obinutuzumab, each NK cell in peripheral blood destroys 25 leukemic cells. |
| format | Online Article Text |
| id | pubmed-6900973 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Future Science Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69009732019-12-11 Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army García-Muñoz, Ricardo Nájera, María-Josefa Feliu, Jesús Antón-Remírez, Judith Ramalle-Gómara, Enrique Marín-Gorricho, Raquel Peralta, Raisa Gutiérrez-Gamarra, Elena Nuñez-Rodriguez, Jessica Zafra-Morales, Ricardo Aguinaga, Lorea Nebot-Villacampa, María-Jose Hernandez-Pérez, Prisma-Monserrat Farfán-Quiroga, Giovanna Panizo, Carlos Domínguez-Garrido, Elena Future Sci OA Research Article AIM: To analyze the effects of subcutaneous or intravenous rituximab + lymphokine-activated killer cells, obinutuzumab or ibrutinib on natural killer (NK) cell levels in chronic lymphocytic leukemia and follicular lymphoma patients. PATIENTS & METHODS: The distribution of peripheral blood NK cells of 31 patients was analyzed by flow cytometry. RESULTS: We detected a decrease of NK cells in peripheral blood below normal range after obinutuzumab treatment. During maintenance treatment with subcutaneous rituximab, an NK cell reduction was less pronounced than after intravenous rituximab treatment, despite lymphokine-activated killer cell infusions. CONCLUSION: After one dose of obinutuzumab, each NK cell in peripheral blood destroys 25 leukemic cells. Future Science Ltd 2019-11-26 /pmc/articles/PMC6900973/ /pubmed/31827894 http://dx.doi.org/10.2144/fsoa-2019-0064 Text en © 2019 Ricardo Garcia-Munoz This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
| spellingShingle | Research Article García-Muñoz, Ricardo Nájera, María-Josefa Feliu, Jesús Antón-Remírez, Judith Ramalle-Gómara, Enrique Marín-Gorricho, Raquel Peralta, Raisa Gutiérrez-Gamarra, Elena Nuñez-Rodriguez, Jessica Zafra-Morales, Ricardo Aguinaga, Lorea Nebot-Villacampa, María-Jose Hernandez-Pérez, Prisma-Monserrat Farfán-Quiroga, Giovanna Panizo, Carlos Domínguez-Garrido, Elena Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title | Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title_full | Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title_fullStr | Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title_full_unstemmed | Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title_short | Battle of Thermopylae: 300 Spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of Xerxes’ army |
| title_sort | battle of thermopylae: 300 spartans (natural killer cells plus obinutuzumab) versus the immortal warriors (chronic lymphocytic leukemia cells) of xerxes’ army |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900973/ https://www.ncbi.nlm.nih.gov/pubmed/31827894 http://dx.doi.org/10.2144/fsoa-2019-0064 |
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