Cargando…
TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumorigenesis
The kinase TBK1 responds to microbial stimuli and mediates type I interferon (IFN-I) induction. We show that TBK1 is also a central mediator of growth factor signaling; this function relies on a specific adaptor, TBK-binding protein 1 (TBKBP1). TBKBP1 recruits TBK1 to PKCθ via a scaffold protein, Ca...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901116/ https://www.ncbi.nlm.nih.gov/pubmed/31792381 http://dx.doi.org/10.1038/s41556-019-0429-8 |