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Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL
Apoptosis is a form of programmed cell death in multicellular organisms. Bcl-2 prevents apoptosis and promotes cellular survival by neutralizing BH3 domain-containing proteins, which directly activate the pore-forming proteins BAX and BAK. However, Bcl-2 is not known to regulate other cell death eff...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901440/ https://www.ncbi.nlm.nih.gov/pubmed/31839993 http://dx.doi.org/10.1038/s41420-019-0230-2 |