Cargando…
Cdc7 kinase stimulates Aurora B kinase in M-phase
The conserved serine-threonine kinase, Cdc7, plays a crucial role in initiation of DNA replication by facilitating the assembly of an initiation complex. Cdc7 is expressed at a high level and exhibits significant kinase activity not only during S-phase but also during G2/M-phases. A conserved mitoti...
Autores principales: | Ito, Sayuri, Goto, Hidemasa, Kuniyasu, Kinue, Shindo, Mayumi, Yamada, Masayuki, Tanaka, Kozo, Toh, Gaik-Theng, Sawa, Masaaki, Inagaki, Masaki, Bartek, Jiri, Masai, Hisao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901529/ https://www.ncbi.nlm.nih.gov/pubmed/31819079 http://dx.doi.org/10.1038/s41598-019-54738-2 |
Ejemplares similares
-
Drug design with Cdc7 kinase: a potential novel cancer therapy target
por: Sawa, Masaaki, et al.
Publicado: (2009) -
ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
por: Yamada, Masayuki, et al.
Publicado: (2013) -
Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells
por: Yang, Chi-Chun, et al.
Publicado: (2019) -
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells
por: Yang, Chi-Chun, et al.
Publicado: (2016) -
Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A Review
por: Gavriilidis, Paschalis, et al.
Publicado: (2015)