Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma

Epithelial–mesenchymal transition (EMT) plays a crucial role in hepatocellular carcinoma (HCC) progression. Hypoxia and excessive transforming growth factor-β (TGF-β) have been identified as inducers and target for EMT in HCC. Here, we show hypoxia inducible factor-1α (HIF-1α) and TGF-β form a feed-...

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Detalles Bibliográficos
Autores principales: Su, Qi, Fan, Mengying, Wang, Jingjing, Ullah, Asmat, Ghauri, Mohsin Ahmad, Dai, Bingling, Zhan, Yingzhuan, Zhang, Dongdong, Zhang, Yanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901539/
https://www.ncbi.nlm.nih.gov/pubmed/31819036
http://dx.doi.org/10.1038/s41419-019-2173-1

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