A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL

We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the CCDC6 and RET genes. Although the RET mutations have been identified before in other malignancies, and it is thought to represent a driver mutation in these neoplasms, i...

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Autores principales: Mejia Saldarriaga, Mateo, Steinberg, Amir, Severson, Eric A., Binder, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901674/
https://www.ncbi.nlm.nih.gov/pubmed/31850206
http://dx.doi.org/10.3389/fonc.2019.01303
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author Mejia Saldarriaga, Mateo
Steinberg, Amir
Severson, Eric A.
Binder, Adam
author_facet Mejia Saldarriaga, Mateo
Steinberg, Amir
Severson, Eric A.
Binder, Adam
author_sort Mejia Saldarriaga, Mateo
collection PubMed
description We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the CCDC6 and RET genes. Although the RET mutations have been identified before in other malignancies, and it is thought to represent a driver mutation in these neoplasms, it has yet to be described in ALL. The identification of known fusion genes conferring activating tyrosine kinase activity in neoplasms can suggest potential therapeutic role of tyrosine kinase inhibitors (TKI), an approach that has been exploited in several other fusion genes.
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spelling pubmed-69016742019-12-17 A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL Mejia Saldarriaga, Mateo Steinberg, Amir Severson, Eric A. Binder, Adam Front Oncol Oncology We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the CCDC6 and RET genes. Although the RET mutations have been identified before in other malignancies, and it is thought to represent a driver mutation in these neoplasms, it has yet to be described in ALL. The identification of known fusion genes conferring activating tyrosine kinase activity in neoplasms can suggest potential therapeutic role of tyrosine kinase inhibitors (TKI), an approach that has been exploited in several other fusion genes. Frontiers Media S.A. 2019-12-03 /pmc/articles/PMC6901674/ /pubmed/31850206 http://dx.doi.org/10.3389/fonc.2019.01303 Text en Copyright © 2019 Mejia Saldarriaga, Steinberg, Severson and Binder. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Mejia Saldarriaga, Mateo
Steinberg, Amir
Severson, Eric A.
Binder, Adam
A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title_full A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title_fullStr A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title_full_unstemmed A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title_short A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL
title_sort case of ccdc6-ret fusion mutation in adult acute lymphoblastic leukemia (all), a known activating mutation reported in all
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901674/
https://www.ncbi.nlm.nih.gov/pubmed/31850206
http://dx.doi.org/10.3389/fonc.2019.01303
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