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Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function

Epigenetic programs that control posttranslational modifications of histone proteins and DNA itself tightly regulate transcriptional networks determining the identity and function of CD8(+) T cells. Chromatin-modifying enzymes such as histone acetyltransferases and deacetylases, represent key molecu...

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Autores principales: Yerinde, Cansu, Siegmund, Britta, Glauben, Rainer, Weidinger, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901948/
https://www.ncbi.nlm.nih.gov/pubmed/31849941
http://dx.doi.org/10.3389/fimmu.2019.02718
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author Yerinde, Cansu
Siegmund, Britta
Glauben, Rainer
Weidinger, Carl
author_facet Yerinde, Cansu
Siegmund, Britta
Glauben, Rainer
Weidinger, Carl
author_sort Yerinde, Cansu
collection PubMed
description Epigenetic programs that control posttranslational modifications of histone proteins and DNA itself tightly regulate transcriptional networks determining the identity and function of CD8(+) T cells. Chromatin-modifying enzymes such as histone acetyltransferases and deacetylases, represent key molecular determinants of the epigenetic imprinting of CD8(+) T cells. The functions of these enzymes highly depend on the availability of key products of cellular metabolism pathways such as acetyl-CoA, NAD (Nicotinamide adenine dinucleotide) and SEM (S-adenosylmethionine), suggesting that there is a close crosstalk between the metabolic and the epigenetic regulation of CD8(+) T cells. In this review, we will discuss the metabolic regulation of CD8(+) T cell epigenetics during activation and differentiation. We will furthermore summarize how metabolic signals from the tumor microenvironment (TME) shape the epigenetic landscape of CD8(+) T cells to better understand the mechanism underlying CD8(+) T cell exhaustion in anti-tumor and anti-viral immunity, which might help to overcome limitations of current CD8(+) T cell-based therapies.
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spelling pubmed-69019482019-12-17 Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function Yerinde, Cansu Siegmund, Britta Glauben, Rainer Weidinger, Carl Front Immunol Immunology Epigenetic programs that control posttranslational modifications of histone proteins and DNA itself tightly regulate transcriptional networks determining the identity and function of CD8(+) T cells. Chromatin-modifying enzymes such as histone acetyltransferases and deacetylases, represent key molecular determinants of the epigenetic imprinting of CD8(+) T cells. The functions of these enzymes highly depend on the availability of key products of cellular metabolism pathways such as acetyl-CoA, NAD (Nicotinamide adenine dinucleotide) and SEM (S-adenosylmethionine), suggesting that there is a close crosstalk between the metabolic and the epigenetic regulation of CD8(+) T cells. In this review, we will discuss the metabolic regulation of CD8(+) T cell epigenetics during activation and differentiation. We will furthermore summarize how metabolic signals from the tumor microenvironment (TME) shape the epigenetic landscape of CD8(+) T cells to better understand the mechanism underlying CD8(+) T cell exhaustion in anti-tumor and anti-viral immunity, which might help to overcome limitations of current CD8(+) T cell-based therapies. Frontiers Media S.A. 2019-11-26 /pmc/articles/PMC6901948/ /pubmed/31849941 http://dx.doi.org/10.3389/fimmu.2019.02718 Text en Copyright © 2019 Yerinde, Siegmund, Glauben and Weidinger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yerinde, Cansu
Siegmund, Britta
Glauben, Rainer
Weidinger, Carl
Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title_full Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title_fullStr Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title_full_unstemmed Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title_short Metabolic Control of Epigenetics and Its Role in CD8(+) T Cell Differentiation and Function
title_sort metabolic control of epigenetics and its role in cd8(+) t cell differentiation and function
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901948/
https://www.ncbi.nlm.nih.gov/pubmed/31849941
http://dx.doi.org/10.3389/fimmu.2019.02718
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