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Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity
Consumers are exposed to thousands of chemicals with potentially adverse health effects. However, these chemicals will never be tested for toxicity because of the immense resources needed for animal-based (in vivo) toxicological studies. Today, there are no viable in vitro alternatives to these type...
Autores principales: | Schyman, Patric, Printz, Richard L., Estes, Shanea K., O’Brien, Tracy P., Shiota, Masakazu, Wallqvist, Anders |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901980/ https://www.ncbi.nlm.nih.gov/pubmed/31850077 http://dx.doi.org/10.3389/fgene.2019.01233 |
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