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The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair
DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication errors. In Escherichia coli, initiation of MMR involves recognition of the mismatch by MutS, recruitment of MutL, activation of endonuclease MutH and DNA strand incision at a hemimethylated GATC site. Here, we stu...
Autores principales: | Mardenborough, Yannicka S N, Nitsenko, Katerina, Laffeber, Charlie, Duboc, Camille, Sahin, Enes, Quessada-Vial, Audrey, Winterwerp, Herrie H K, Sixma, Titia K, Kanaar, Roland, Friedhoff, Peter, Strick, Terence R, Lebbink, Joyce H G |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902014/ https://www.ncbi.nlm.nih.gov/pubmed/31598722 http://dx.doi.org/10.1093/nar/gkz834 |
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