Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor

We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Leibetseder, Annette, Wagner, Judith, Tomasits, Josef, Haring, Hans-Peter, Hutterer, Markus, Trenkler, Johannes, von Oertzen, Tim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902021/
https://www.ncbi.nlm.nih.gov/pubmed/31849820
http://dx.doi.org/10.3389/fneur.2019.01257
_version_ 1783477607343325184
author Leibetseder, Annette
Wagner, Judith
Tomasits, Josef
Haring, Hans-Peter
Hutterer, Markus
Trenkler, Johannes
von Oertzen, Tim J.
author_facet Leibetseder, Annette
Wagner, Judith
Tomasits, Josef
Haring, Hans-Peter
Hutterer, Markus
Trenkler, Johannes
von Oertzen, Tim J.
author_sort Leibetseder, Annette
collection PubMed
description We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding for the human serotonin transporter (SERT). Pathophysiological and clinical implications of these findings are discussed.
format Online
Article
Text
id pubmed-6902021
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69020212019-12-17 Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor Leibetseder, Annette Wagner, Judith Tomasits, Josef Haring, Hans-Peter Hutterer, Markus Trenkler, Johannes von Oertzen, Tim J. Front Neurol Neurology We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding for the human serotonin transporter (SERT). Pathophysiological and clinical implications of these findings are discussed. Frontiers Media S.A. 2019-11-26 /pmc/articles/PMC6902021/ /pubmed/31849820 http://dx.doi.org/10.3389/fneur.2019.01257 Text en Copyright © 2019 Leibetseder, Wagner, Tomasits, Haring, Hutterer, Trenkler and von Oertzen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Leibetseder, Annette
Wagner, Judith
Tomasits, Josef
Haring, Hans-Peter
Hutterer, Markus
Trenkler, Johannes
von Oertzen, Tim J.
Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title_full Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title_fullStr Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title_full_unstemmed Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title_short Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor
title_sort spontaneous intracerebral hemorrhage due to delta storage pool disease in a patient on a serotonin-norepinephrine reuptake inhibitor
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902021/
https://www.ncbi.nlm.nih.gov/pubmed/31849820
http://dx.doi.org/10.3389/fneur.2019.01257
work_keys_str_mv AT leibetsederannette spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT wagnerjudith spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT tomasitsjosef spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT haringhanspeter spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT hutterermarkus spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT trenklerjohannes spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor
AT vonoertzentimj spontaneousintracerebralhemorrhageduetodeltastoragepooldiseaseinapatientonaserotoninnorepinephrinereuptakeinhibitor

Ejemplares similares