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Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials
BACKGROUND: Funding and resources for low prevalent neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) are limited, and optimising their use is vital for efficient drug development. In this study, we review the design assumptions for pivotal ALS clinical trials with time-to-even...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902062/ https://www.ncbi.nlm.nih.gov/pubmed/31292200 http://dx.doi.org/10.1136/jnnp-2019-320998 |