Uncovering the Resistance Mechanism of Mycobacterium tuberculosis to Rifampicin Due to RNA Polymerase H451D/Y/R Mutations From Computational Perspective

Tuberculosis is still one of the top 10 causes of deaths worldwide, especially with the emergence of multidrug-resistant tuberculosis. Rifampicin, as the most effective first-line antituberculosis drug, also develops resistance due to the mutation on Mycobacterium tuberculosis (Mtb) RNA polymerase....

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Detalles Bibliográficos
Autores principales: Zhang, Qianqian, An, Xiaoli, Liu, Hongli, Wang, Shuo, Xiao, Tong, Liu, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902089/
https://www.ncbi.nlm.nih.gov/pubmed/31850310
http://dx.doi.org/10.3389/fchem.2019.00819

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