ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Using natural history data,...

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Detalles Bibliográficos
Autores principales: Lerner, Shaul, Anderzhanova, Elmira, Verbitsky, Sima, Eilam, Raya, Kuperman, Yael, Tsoory, Michael, Kuznetsov, Yuri, Brandis, Alexander, Mehlman, Tevie, Mazkereth, Ram, McCarter, Robert, Segal, Menahem, Nagamani, Sandesh C.S., Chen, Alon, Erez, Ayelet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902269/
https://www.ncbi.nlm.nih.gov/pubmed/31747589
http://dx.doi.org/10.1016/j.celrep.2019.10.043

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